PRODUCT 製品概要
様々なアプリケーション
- 毒性学、寿命・老化、走化性、酸化ストレス、駆虫剤、生態毒性、RNAiなど
幅広い検討対象
- 線虫, 寄生虫, ゼブラフィッシュなどの小型生物に対応
導⼊が容易
- 6, 12, 24, 48, 96F, 96U, 384 well plateで使用可能
対象へのダメージレス
- 非侵襲性の赤外線検出方式により、対象へのダメージを低減
FEATURES 特徴
マイクロプレートで培養される小型生物の活動量を自動測定
- ユーザー指定の各WellまたはGroup毎の活動量を測定
- 測定時間最大 32000 分まで設定可能
- CSVファイル出力、専用ソフトウェアでのデータ分析
- 平均活動量、総活動量、標準誤差のデータ算出
WMicrotracker ONEは、対象生物が赤外線マイクロビームを通過する時に生じる光の散乱を検出する方式を採用しています。
マイクロビームのチャンネル数は384個(波長880nm、直径100um、電力1mW/mm2 未満)、96well plateの場合１well当たり2本のビームが照射されます。
対象がマイクロビームの光を散乱させると、動きとして認識・カウントされ、設定時間内の累積活動量を計測することができます。
高感度マイクロビームによるPhylumtech社の革新的技術は、微生物や小型生物の活動量を定量化できます。
WMicrotracker ONEは以下の国際特許に基づいて保護されています。
National Research Council CONICET (P20060105084AR, PCT/IB2007/054628, EPO & US patent granted) and licensed to PHYLUMTECH S.A. All rights reserve
APPLICATIONSアプリケーション
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EFFECTS OF ALDICARB AND LEVAMISOLE IN C.ELEGANS
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OXIDATIVE STRESS IN C.ELEGANS
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BACTERIAL INFECTION IN C.ELEGANS
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BACTERIAL INFECTION IN C.ELEGANS
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TOXICITY IN ZEBRAFISH
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DISEASE MODEL IN ZEBRAFISH: EPILEPSY
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ECHINOCOCCUS GRANULOSUS MOTILITY MEASUREMENT
Publication 論文
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Triazole Fungicides Inhibit Zebrafish Hatching by Blocking the Secretory Function of Hatching Gland Cells
Javiera F. De la Paz, Natalia Beiza, Susana Paredes-Zúñiga, Misque S. Hoare, and Miguel L. Allende
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Use of Caenorhabditis elegans based assays as an alternative strategy in toxicity testing
Author(s)Gregori Balaguer, María Tutor(s)Sanmartín Santos, Isaias Salvador
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High-Throughput Phenotypic Assay to Screen for Anthelmintic Activity on Haemonchus contortus
Aya C. Taki ,Joseph J. Byrne ,Tao Wang ,Brad E. Sleebs,Nghi Nguyen ,Ross S. Hall,Pasi K. Korhonen,Bill C.H. Chang,Paul Jackson,Abdul Jabbarand Robin B. Gasser
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Chemical characterization and in vitro anthelmintic activity of Citrus bergamia Risso and Citrus X paradisii Macfad essential oil against Haemonchus contortus Kirby isolate
Vivien PatriciaGarbin, BeatrizMunguía, Jenny CarolinSaldaña, Cícero Deschamps, Roger Raupp Cipriano, Marcelo Beltrão Molentoa
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Sensitivity of Haemonchus contortus to anthelmintics using different in vitro screening assays: a comparative study
Beatriz Munguía, Jenny Saldaña, Magdalena Nieves, María Elisa Melian, Manuela Ferrer, Ramiro Teixeira, Williams Porcal, Eduardo Manta & Laura Domínguez
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Screening of a drug repurposing library with a nematode motility assay identifies promising anthelmintic hits against Cooperia oncophora and other ruminant parasites
Maoxuan Liu, Bart Landuyt, bHugo Klaassen, Peter Geldhof, Walter Luyten
(System: WMicrotracker ONE Model organism: Nematode)
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A validated high-throughput method for assaying rat lungworm (Angiostrongylus cantonensis) motility when challenged with potentially anthelmintic natural products from Hawaiian fungi
Randi L. Rollins, Mallique Qader, William L. Gosnell, Cong Wang, Shugeng Cao and Robert H. Cowie
(System: WMicrotracker ONE Model organism: A.cantonensis)
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In vitro screening methods for parasites: the wMicroTracker & the WormAssay
Emma Gunderson, Christina Bulman, Mona Luo, and Judy Sakanari
(System: WMicrotracker ONE Model organism: Parasites)
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Disruption of genes associated with Charcot-Marie-Tooth type 2 lead to common behavioural, cellular and molecular defects in Caenorhabditis elegans
Ming S. Soh,Xinran Cheng,Tarika Vijayaraghavan,Arwen Vernon,Jie Liu,Brent Neumann
(System: WMicrotracker ONE Model organism: C.elegans)
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A single copy transgenic mutant FUS strain reproduces age-dependent ALS phenotypes in C. elegans
Audrey Labarre,Gilles Tossing,Claudia Maios,ames J Doyle,and J Alex Parker
(System: WMicrotracker ONE Model organism: C.elegans)
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Caenorhabditis elegans Infrared-Based Motility Assay Identified New Hits for Nematicide Drug Development
Gastón Risi,Elena Aguilera,Enrique Ladós,Gonzalo Suárez,Inés Carrera,4ORCID,Guzmán Álvarez,and Gustavo Salinas
(System: WMicrotracker ONE Model organism: C.elegans)
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Biochemical characterization, cytotoxic, antimutagenic, anticancer and molecular docking studies on Tecomella undulata
SanaRiaz,Muhammad ArslanJaved, IqraNawaz, TariqJaved,
(System: WMicrotracker ONE Model organism: C.elegans)
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Small Molecule Rescue of ATXN3 Toxicity in C. elegans via TFEB/HLH-30
Yasmin Fardghassemi, Claudia Maios & J. Alex Parker
(System: WMicrotracker ONE Model organism: C.elegans)
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Assessment of the effects of organic vs. inorganic arsenic and mercury in Caenorhabditis elegans
JessicaCamachoaAlinede ContibIgor P.PogribnybRobert L.SprandoaPiper ReidHunta
(System: WMicrotracker ONE Model organism: C.elegans)
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Disruption of mitochondrial dynamics affects behaviour and lifespan in Caenorhabditis elegans
Joseph J. Byrne, Ming S. Soh, Gursimran Chandhok, Tarika Vijayaraghavan, Jean-Sébastien Teoh, Simon Crawford, Ansa E. Cobham, Nethmi M. B. Yapa, Christen K. Mirth & Brent Neumann
(System: WMicrotracker ONE Model organism: C.elegans)
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Bioassay-guided isolation of three anthelmintic compounds from Warburgia ugandensis Sprague subspecies ugandensis, and the mechanism of action of polygodial
MaoxuanLiu PurityKipanga Anh HungMai InekeDhondt Bart P.Braeckman Wim De Borggraeve
WalterLuyten(System: WMicrotracker ONE Model organism: C.elegans)
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C. elegans Development and Activity Test detects mammalian developmental neurotoxins
Piper ReidHunt NicholasOlejnik Keenan D.BaileyCory A.VaughtRobert L.Sprando
(System: WMicrotracker ONE Model organism: C.elegans)
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Antibacterial, Antifungal, Antiviral, and Anthelmintic Activities of Medicinal Plants of Nepal Selected Based on Ethnobotanical Evidence
Bishnu Joshi ,Sujogya Kumar Panda ,Ramin Saleh Jouneghani,Maoxuan Liu,1 Niranjan Parajuli ,Pieter Leyssen,Johan Neyts,and Walter Luyten
(System: WMicrotracker ONE Model organism: C.elegans)
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Increased sensitivity of an infrared motility assay for nematicide discovery
Franco Vairoletti,Antonela Baron, Cecilia Saiz,Graciela Mahler,and Gustavo Salinas
(System: WMicrotracker ONE Model organism: C.elegans)
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Practical High-Throughput Method to Screen Compounds for Anthelmintic Activity against Caenorhabditis elegans
Aya C. Taki Joseph J. Byrne Peter R. Boag 2Abdul Jabbar and Robin B. Gasser
(System: WMicrotracker ONE Model organism: C.elegans)
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Comparison of electrophysiological and motility assays to study anthelmintic effects in Caenorhabditis elegans
Steffen R.Hahnela1William M.RobertsbIringHeisleraDanielKulkea2Janis C.Weeksb
(System: WMicrotracker ONE Model organism: C.elegans)
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The nervous and prenervous roles of serotonin in Echinococcus spp
F Camicia , M Herz, L C Prada, L Kamenetzky, S H Simonetta, M A Cucher, J I Bianchi, C Fernández, K Brehm, M C Rosenzvit
(System: ONE, Model organism: Echinococcus spp)
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An automated tracking system for Caenorhabditis elegans locomotor behavior and circadian studies application
ergio H Simonetta, Diego A Golombek
(System: ONE, Model organism: C. Elegans)
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Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons
Julie Vérièpe, Lucresse Fossouo, J Alex Parker
(System: ONE, Model organism: C. Elegans)
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Reliable Screening of Dye Phototoxicity by Using a Caenorhabditis elegans Fast Bioassay
Javier Ignacio Bianchi, Juan Carlos Stockert, Lucila Ines Buzzi, Alfonso Blázquez-Castro, Sergio Hernán Simonetta
(System: ONE, Model organism: C. Elegans)
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Bioactivity of nanosilver in Caenorhabditis elegans: Effects of size, coat, and shape
Piper ReidHuntaZacharyKeltneraXiugongGaoaSteven J.OldenburgbPriyankaBushanaaNicholasOlejnikaRobert L.Sprandoa
(System: ONE, Model organism: C. Elegans)
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Development of Nutraceutical Emulsions as Risperidone Delivery Systems: Characterization and Toxicological Studies
Daniela Edith Igartúa, María Natalia Calienni, Daniela Agustina Feas, Nadia Silvia Chiaramoni, Silvia Del Valle Alonso, María Jimena Prieto
(System: ONE, Model organism: Zebrafish)
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Reliable Screening of Dye Phototoxicity by Using a Caenorhabditis elegans Fast Bioassay.
Javier Ignacio Bianchi, Juan Carlos Stockert, Lucila Ines Buzzi, Alfonso Blázquez-Castro, Sergio Hernán Simonetta
(System: ONE ,Model organism: C. Elegans)
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Optimization of a locomotion-based zebrafish seizure model
Philip Anthony Gilbert Shaw, Sujogya Kumar Panda, Alexandru Stanca, Walter Luyten
(System: ONE, Model organism: Zebrafish)
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Nutraceutical emulsion containing valproic acid (NE-VPA): a drug delivery system for reversion of seizures in zebrafish larvae epilepsy model
Daniela Agustina Feas· Daniela Edith Igartúa· María Natalia Calienni·
Carolina Soledad Martinez· Marina Pifano· Nadia Silvia Chiaramoni·
Silvia del Valle Alonso · María Jimena Prieto(System: ONE, Model organism: Zebrafish)
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Set-up of an infrared fast behavioral assay using zebrafish (Danio rerio) larvae, and its application in compound biotoxicity screening
Darío Bicharaa,b, Nora B. Calcaterrab, Silvia Arranzb, Pablo Armasb and
Sergio H. Simonettaa(System: ONE, Model organism: Zebrafish)
SPECIFICATIONS スペック
| WMicrotracker One | |
| 培養容器 | 6, 12, 24, 48, 96F, 96U, 384 well plate |
|---|---|
| 赤外線チャンネル数 | 384 |
| 対象サイズ | At least 500 um in size |
| スキャン回数 | 5 times/sec |
| 処理量 | 2 minutes time block resolution |
| 推奨最短測定時間(プレートあたり) | 15分 |
| 温度調節機能 | 無 |
| 対応培地 | 液体 |
| 寸法 | W220 x D280 x H91 mm |
| 品名 | 培養容器 | 赤外線チャンネル数 | 対象サイズ | スキャン回数 | 処理量 | 推奨最短測定時間(プレートあたり) | 温度調節機能 | 対応培地 | 寸法 |
|---|---|---|---|---|---|---|---|---|---|
| WMicrotracker ONE | 6, 24, 96F, 96U, 384 well plate | 384 | At least 500 um in size | 5 times/sec | 2 minutes time block resolution | 15分 | 無 | 液体 | W220 x D280 x H91 mm |