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PREDICTING METABOLISM-RELATED DRUG-DRUG INTERACTIONS USING A MULTI-TISSUE MICROPHYSIOLOGICAL SYSTEM
Christian Lohasz, Flavio Bonanini, Kasper Renggli, Olivier Frey, and Andreas Hierlemann.
ETH Zurich NO. 26595, 2020 -
Co-Microencapsulation of Islets and MSC CellSaics, Mosaic-Like Aggregates of MSCs and Recombinant Peptide Pieces, and Therapeutic Effects of Their Subcutaneous Transplantation on Diabetes
Yusuke Mochizuki, Ryo Kogawa, Ryuta Takegami, Kentaro Nakamura, Akira Wakabayashi, Tadashi Ito and Yasuhiro Yoshioka
Biomedicines 2020, 8(9), 318; Published: 31 August 2020 -
Preclinical Evaluation of the Novel Small-Molecule MSI-N1014 for Treating Drug-Resistant Colon Cancer via the LGR5/β-catenin/miR-142-3p Network and Reducing Cancer-Associated Fibroblast Transformation
Vijesh Kumar Yadav, Yan-Jiun Huang, Thomashire Anita Georg, Po-Li Wei, Maryam rachmawati Sumitra, Ching-Liang Ho, Tzu-Hao Chang, Alexander T. H. Wu and Hsu-Shan Huang
Cancers 2020, 12(6), 1590; Published: 16 June 2020 -
Parallelized Wireless Sensing System for Continuous Monitoring of Microtissue Spheroids
Lei Dong, Paolo S. Ravaynia, Qing-An Huang, Andreas Hierlemann, and Mario M. Modena
ACS Sens. 2020, 5, 7, 2036–2043, Publication Date:June 10, 2020 -
Promoter-Level Transcriptome Identifies Stemness Associated With Relatively High Proliferation in Pancreatic Cancer Cells
Ru Chen, Aiko Sugiyama, Naoyuki Kataoka, Masahiro Sugimoto, Shoko Yokoyama, Akihisa Fukuda, Shigeo Takaishi and Hiroshi Seno
Frontiers in Oncology Gastrointensitial Cancers, 20 March 2020 -
A 3D Heterotypic Multicellular Tumor Spheroid Assay Platform to Discriminate Drug Effects on Stroma versus Cancer Cells
Zoe Weydert, Madhu Lal-Nag, Lesley Mathews-Greiner, Christoph Thiel, Henrik Cordes, Lars Küpfer, Patrick Guye, Jens M. Kelm, Marc Ferrer
SLAS Volume: 25 issue: 3, page(s): 265-276 October 29, 2019 -
Wild-type TP53 defined gamma-secretase inhibitor sensitivity and synergistic activity with doxorubicin in GSCs
Chen Zhang, Emmanuel Martinez-Ledesma, Feng Gao, Wei Zhang, Jie Ding, Shaofang Wu, Xiaolong Li, Jimin Wu, Ying Yuan, Dimpy Koul, and WK Alfred Yung
Am J Cancer Res. 2019; 9(8): 1734–1745. 2019 Aug 1. -
Monospecific antibody targeting of CDH11 inhibits epithelial-to-mesenchymal transition and represses cancer stem cell-like phenotype by up-regulating miR-335 in metastatic breast cancer, in vitro and in vivo
Jia-Hong Chen, Wen-Chien Huang, Oluwaseun Adebayo Bamodu, Peter Mu-Hsin Chang, Tsu-Yi Chao & Tse-Hung Huang
BMC Cancer volume 19, Article number: 634 (2019 -
A novel electron emission-based cell culture device promotes cell proliferation and differentiation of pre-osteoblastic MC3T3-E1 cells
Fumiaki Sugimori, Hiroyuki Hirakawa, Ai Tsutsui, Hiroyuki Yamaji, Shohei Komaru, Mai Takasaki, Tadashi Iwamatsu, Toshimasa Uemura, Yo Uemura, Kenichi Morita, Takashi Tsumura
PLOS, March 28, 2019 -
Automated, high-throughput measurement of size and growth curves of small organisms in well plates
James Duckworth, Tjalling Jager & Roman Ashauer
Scientific Reportsvolume 9, Article number: 10 (2019) -
Acquired JHDM1D–BRAF Fusion Confers Resistance to FGFR Inhibition in FGFR2-Amplified Gastric Cancer
Hitoshi Sase, Yoshito Nakanishi, Satoshi Aida, Kana Horiguchi-Takei, Nukinori Akiyama, Toshihiko Fujii, Kiyoaki Sakata, Toshiyuki Mio, Masahiro Aoki and Nobuya Ishii
Molecular cancer theraputics-17-1022 Published October 2018 -
Up-regulation of Bone Morphogenetic Protein 7 by 2-Hydroxycinnamaldehyde Attenuates HNSCC Cell Invasion
SUNG-MIN KANG1, JINKYUNG KIM1, SOO HYUN KANG1, SU YOUNG OH1, HEON-JIN LEE1, BYOUNG-MOG KWON2 and SU-HYUNG HONG1
Anticancer Research October 2018 vol. 38 no. 10 5747-5757 -
Sertraline, chlorprothixene, and chlorpromazine characteristically interact with the REST-binding site of the corepressor mSin3, showing medulloblastoma cell growth inhibitory activities
Jun-ichi Kurita, Yuuka Hirao, Hirofumi Nakano, Yoshifumi Fukunishi & Yoshifumi Nishimura.
Scientific Reports 8, Article number: 13763 (2018). -
Single cell analysis of Crohn’s disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties
Kohei Suzuki, Tatsuro Murano, Hiromichi Shimizu, Go Ito, Toru Nakata, Satoru Fujii, Fumiaki Ishibashi, Ami Kawamoto, Sho Anzai, Reiko Kuno, Konomi Kuwabara, Junichi Takahashi, Minami Hama, Sayaka Nagata, Yui Hiraguri, Kento Takenaka, Shiro Yui, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto.
Journal of Gastroenterology, (2018), 1–13. -
PAF promotes stemness and radioresistance of glioma stem cells
Derrick Sek Tong Ong, Baoli Hu, Yan Wing Ho, Charles-Etienne Gabriel Sauvé, Christopher A. Bristow, Qianghu Wang, Asha S. Multani, Peiwen Chen, Luigi Nezi, Shan Jiang, Claire Elizabeth Gorman, Marta Moreno Monasterio, Dimpy Koul, Matteo Marchesini, Simona Colla, Eun-Jung Jin, Erik P. Sulman, Denise J. Spring, Wai-Kwan Alfred Yung, Roel G. W. Verhaak, Lynda Chin, Y. Alan Wang, and Ronald A. DePinho
PNAS October 24, 2017 114 (43) -
PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells
Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Tatsuro Murano, Go Ito, Hiromichi Shimizu, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Akihiro Araki, Kazuo Ohtsuka, Ryuichi Okamoto, Mamoru Watanabe.
Scientific Reports, (2016), 36795. -
Three-Dimensional Spheroid Cell Culture Model for Target Identification Utilizing High-Throughput RNAi Screens
LaKesla R. Iles, Geoffrey A. Bartholomeusz.
High-Throughput RNAi Screening (2016), 21-135. -
Human Dynactin-Associated Protein Transforms NIH3T3 Cells to Generate Highly Vascularized Tumors with Weak Cell-Cell Interaction
JTatsuki Kunoh, Weixiang Wang, Hiroaki Kobayashi, Daisuke Matsuzaki, Yuki Togo, Masahiro Tokuyama, Miho Hosoi, Koichi Koseki, Shu-ichi Wada, Nobuo Nagai, Toshinobu Nakamura, Shintaro Nomura, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami.
PLOS ONE, (2015), August 18. -
Phenotypic Drug Discovery in 3D, Testing Drug Efficacy by Rapid Size ProfilingOver Time with Tumor Microtissues
Randy Strube, Ph.D., Andreia F.Fernandes, Markus Furter, Jens M. Kelm,Ph.D., and David A. Fluri, Ph.D.
Genetic Engineering & Biotechnology News, (2014), Vol. 34, No. 16. -
High-throughput, bright-field imaging of 3D tumor spheroid growth and morphology for therapeutic and efficacy screening: A study using chemotherapeutic compounds
Leena Mol Thuruthippallil, Jens M. Kelm and David Fluri
Volume 14, Issue 12 Supplement 2, pp. B75 Published December 2015 DOI:https://doi.org/10.1158/1535-7163.TARG-15-B75 -
Issues with Cancer Spheroid Models in Therapeutic Drug Screening
Eleonore Fröhlich
Curr Pharm Des. 2020;26(18):2137-2148. doi: 10.2174/1381612826666200218094200 -
Predicting Metabolism-Related Drug–Drug Interactions Using a Microphysiological Multitissue System
Christian Lohasz,Flavio Bonanini,Lisa Hoelting,Kasper Renggli,Olivier Frey,Andreas Hierlemann
Advanced BiosystemsVolume 4, Issue 11 2000079 First published: 19 October 2020 https://doi.org/10.1002/adbi.202000079 -
Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer
Naphannop Sereesongsaeng, Sara H. McDowell, James F. Burrows, Christopher J. Scott & Roberta E. Burden
Breast Cancer Research volume 22, Article number: 139 (2020) Published:09 December 2020 DOI:https://doi.org/10.1186/s13058-020-01376-6 -
SNAIL regulates gastric carcinogenesis through CCN3 and NEFL
Ru Chen, Kenji Masuo, Akitada Yogo, Shoko Yokoyama, Aiko Sugiyama, Hiroshi Seno, Akihiko Yoshizawa, Shigeo Takaishi
Carcinogenesis, Volume 42, Issue 2, February 2021, Pages 190–201, https://doi.org/10.1093/carcin/bgaa133 Published: 12 December 2020 -
HNC0014, a Multi-Targeted Small-Molecule, Inhibits Head and Neck Squamous Cell Carcinoma by Suppressing c-Met/STAT3/CD44/PD-L1 Oncoimmune Signature and Eliciting Antitumor Immune Responses
Jih-Chin Lee ,Alexander T. H. Wu ,Jia-Hong Chen ,Wen-Yen Huang ,Bashir Lawal ,Ntlotlang Mokgautsi ,Hsu-Shan Huang and Ching-Liang Ho
Cancers 2020, 12(12), 3759; https://doi.org/10.3390/cancers12123759 Published: 14 December 2020 -
PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O6-methylguanine DNA damage in glioblastoma
Shaofang Wu, Xiaolong Li, Feng Gao, John F de Groot, Dimpy Koul, W K Alfred Yung
Neuro-Oncology, Volume 23, Issue 6, June 2021, Pages 920–931, https://doi.org/10.1093/neuonc/noab003 Published: 12 January 2021 -
Regulation of carcinogenesis and mediation through Wnt/β-catenin signaling by 3,3′-diindolylmethane in an enzalutamide-resistant prostate cancer cell line
Chih-Wei Tsao, Jia-Sin Li, Ya-Wen Lin, Sheng-Tang Wu, Tai-Lung Cha & Chin-Yu Liu
Scientific Reports volume 11, Article number: 1239 (2021) Published:13 January 2021 DOI:https://doi.org/10.1038/s41598-020-80519-3 -
Cancer-Associated Fibroblast Subgroups Showing Differential Promoting Effect on HNSCC Progression
Soo Hyun Kang ,Su Young Oh ,Heon-Jin Lee ,Tae-Geon Kwon ,Jin-Wook Kim ,Sung-Tak Lee ,So-Young Choi and Su-Hyung Hong
Cancers 2021, 13(4), 654; Published: 6 February 2021 https://doi.org/10.3390/cancers13040654 -
S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation
MasayasuToyomoto ,AsukaInoue ,KeiIida ,MasatsuguDenawa ,IsaoKii ,Francois MarieNgako Kadji ,TakayukiKishi ,DohyunIm ,TatsuroShimamura ,HiroshiOnogi ,SuguruYoshida ,SoIwata ,JunkenAoki ,TakamitsuHosoya ,MasatoshiHagiwara
Cell Chemical Biology Volume 28, Issue 8, 19 August 2021, Pages 1132-1144.e9 https://doi.org/10.1016/j.chembiol.2021.01.004https://doi.org/10.1016/j.chembiol.2021.01.004 -
Exploiting the anticancer effects of a nitrogen bisphosphonate nanomedicine for glioblastoma multiforme
Lynn N Jena, Lindsey A Bennie, Emma M McErlean, Sreekanth Pentlavalli, Kim Glass, James F Burrows, Vicky L Kett, Niamh E Buckley, Jonathan A Coulter, Nicholas J Dunne & Helen O McCarthy
Journal of Nanobiotechnology volume 19, Article number: 127 (2021) Published:04 May 2021 DOI:https://doi.org/10.1186/s12951-021-00856-x -
Expression and cell transformation activity of dynactin-associated protein isoforms
Xiaobo Yin,Shota Yamada,Hiroaki Kobayashi,Ryota Tanaka,Yuki Togo,Miho Hosoi,Mie Tsuchida,Tatsuki Kunoh,Shuichi Wada,Toshinobu Nakamura,Ryuzo Sasaki,Tamio Mizukami,Makoto Hasegawa
FEBS Open BioVolume 11, Issue 8 p. 2110-2117 First published: 27 May 2021 https://doi.org/10.1002/2211-5463.13202 -
Gene Expression Profiles Associated with Radio-Responsiveness in Locally Advanced Rectal Cancer
Jeeyong Lee ,Junhye Kwon ,DaYeon Kim ,Misun Park ,KwangSeok Kim ,InHwa Bae ,Hyunkyung Kim ,JoonSeog Kong ,Younjoo Kim ,UiSup Shin and EunJu Kim
Biology 2021, 10(6), 500; https://doi.org/10.3390/biology10060500 Published: 3 June 2021 -
Microfluidic Co-Culture Platform to Recapitulate the Maternal–Placental–Embryonic Axis
Julia A. Boos,Patrick M. Misun,Giulia Brunoldi,Lea A. Furer,Leonie Aengenheister,Mario Modena,Nassim Rousset,Tina Buerki-Thurnherr,Andreas Hierlemann
Advanced BiologyVolume 5, Issue 8 2100609 First published: 19 June 2021 https://doi.org/10.1002/adbi.202100609 -
A Patient-Derived Organoid-Based Radiosensitivity Model for the Prediction of Radiation Responses in Patients with Rectal Cancer
Misun Park ,Junhye Kwon ,Joonseog Kong ,Sun Mi Moon ,Sangsik Cho ,Ki Young Yang ,Won Il Jang ,Mi Sook Kim ,Younjoo Kim and Ui Sup Shin
Cancers 2021, 13(15), 3760; https://doi.org/10.3390/cancers13153760 Published: 27 July 2021 -
Differential Angiogenic Potential of 3-Dimension Spheroid of HNSCC Cells in Mouse Xenograft
So-Young Choi ,Soo Hyun Kang ,Su Young Oh ,Kah Young Lee ,Heon-Jin Lee ,Sangil Gum ,Tae-Geon Kwon ,Jin-Wook Kim ,Sung-Tak Lee ,Yoo Jin Hong ,Dae-Geon Kim and Su-Hyung Hong
Int. J. Mol. Sci. 2021, 22(15), 8245; https://doi.org/10.3390/ijms22158245 Published: 31 July 2021 -
Hypoxia-targeted cupric-tirapazamine liposomes potentiate radiotherapy in prostate cancer spheroids
Vera L.Silva, AmaliaRuiz ,AhlamAli ,SaraPereira ,JaniSeitsonen ,JanneRuokolainen ,FionaFurlong ,JonathanCoulter Wafa’ T.Al-Jamal
International Journal of PharmaceuticsVolume 607, 25 September 2021, 121018 doi:https://doi.org/10.1016/j.ijpharm.2021.121018 -
speedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing
Raphaël B. Di Roberto, ProfileRocío Castellanos-Rueda, Fabrice S. Schlatter, Darya Palianina, ProfileOanh T. P. Nguyen, Edo Kapetanovic, ProfileAndreas Hierlemann, ProfileNina Khanna, ProfileSai T. Reddy
biorxiv Posted August 23, 2021. doi: https://doi.org/10.1101/2021.08.23.457342 -
Gamma-Mangostin Isolated from Garcinia mangostana Suppresses Colon Carcinogenesis and Stemness by Downregulating the GSK3β/β-Catenin/CDK6 Cancer Stem Pathway
Alexander THWu ,Yuan-ChiehYeh ,Yan-JunHuang ,NtlotlangMokgautsi ,BashirLawal ,Tse-HungHuang
Phytomedicine Available online 21 October 2021, 153797 DOI:https://doi.org/10.1016/j.phymed.2021.153797 -
Gravity-driven perfusion systems for the physiological culturing of arrays of microtissues
Lohasz, Christian
ETH Zurich published2020-06-10 DOI:https://doi.org/10.3929/ethz-b-000419480