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Cell3iMager Estier
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Visualizing dynamics of angiogenic sprouting from a three-dimensional microvasculature model using stage-top optical coherence tomographyHaruko Takahashi, Keisuke Kato, Kenji Ueyama, Masayoshi Kobayashi, Gunwoong Baik,Yasuhiro Yukawa, Jun-ichi Suehiro, Yukiko T. Matsunaga.
Scientific reports, (2017), 7:42426. -
A Vascular Endothelial Growth Factor-Dependent Sprouting Angiogenesis Assay Based on an In Vitro Human Blood Vessel Model for the Study of Anti-Angiogenic DrugsJoris Pauty, Ryo Usuba, Irene Gayi Cheng, Louise Hespel, Haruko Takahashi, Keisuke Kato, Masayoshi Kobayashi, Hiroyuki Nakajima, Eujin Lee, Florian Yger, Fabrice Soncin, Yukiko T. Matsunaga.
EBioMedicine, (2018), 27: 225–236. -
A 3D in vitro pericyte-supported microvessel model: visualisation and quantitative characterisation of multistep angiogenesis
Eujin Lee, Haruko Takahashi, Joris Pauty, Masayoshi Kobayashi, Keisuke Kato, Maki Kabara, Jun-ichi Kawabe and Yukiko T. Matsunaga.
Journal of Materials Chemistry B, (2018), 6; 1085-1094. -
EGFL7 regulates sprouting angiogenesis and endothelial integrity in a human blood vessel model
Ryo Usuba, Joris Pauty, Fabrice Soncin, and Yukiko T.Matsunaga
Biomaterials, Volume 197, March 2019, Pages 305-316 -
Directed differentiation of human induced pluripotent stem cells into mature stratified bladder urothelium
Kotaro Suzuki, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Nobuyuki Hinata, Masato Fujisawa & Takashi Aoi
Scientific Reports volume 9, Article number: 10506 (2019) -
A simple three-dimensional gut model constructed in a restricted ductal microspace induces intestinal epithelial cell integrity and facilitates absorption assays
adaaki Nakajima, Katsunori Sasaki, Akihiro Yamamori, Kengo Sakurai, Kaori Miyata, Tomoyuki Watanabe and Yukiko T Matsunaga
Biomater. Sci., 2020, First published:31 Aug 2020
Cell3iMager duos/duos2
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Fetal bovine serum enlarges the size of human pancreatic cancer spheres accompanied by an increase in the expression of cancer stem cell markers
Norihiko Sasaki, Masashi Toyoda, Fumio Hasegawa, Masakazu Fujiwara, Fujiya Gomi b, Toshiyuki Ishiwata.
Biochemical and Biophysical Research Communications, Vol. 514, Issue 1, 18 June 2019, Pages 112-117. -
Ganglioside GM2, highly expressed in the MIA PaCa-2 pancreatic ductal adenocarcinoma cell line, is correlated with growth, invasion, and advanced stage
Norihiko Sasaki, Kenichi Hirabayashi, Masaki Michishita, Kimimasa Takahashi, Fumio Hasegawa, Fujiya Gomi, Yoko Itakura, Naoya Nakamura, Masashi Toyoda,Toshiyuki Ishiwata
Scientific Reports volume 9, Article number: 19369 (2019) -
Hydrodynamic stress stimulates growth of cell clusters via the ANXA1/PI3K/AKT axis in colorectal cancer
Takeshi Hagihara, Jumpei Kondo, Hiroko Endo, Masayuki Ohue, Yoshiharu Sakai and Masahiro Inoue
Scientific Reports volume 9, Article number: 20027 (2019) -
Novel bone microenvironment model of prostate cancer with chitosan fiber matrix and osteoblast in 3D culture
Masahiro Samoto, Hiroaki Matsumoto, Hiroshi Hirata, Sho Ozawa, Junichi Mori, Ryo Inoue, Seiji Yano,
Yoshiaki Yamamoto and Hideyasu Matsuyama
AACR 10.1158/1538-7445.AM2020-321 Published August 2020 -
The anti-inflammatory effect of the gut lactic acid bacteria-generated metabolite 10-oxo-cis-6,trans-11-octadecadienoic acid on monocytes
Shuhei Hagiwara, Kazuki Nagata, Kazumi Kasakura, Fumiya Sakata, Shigenobu Kishino, Jun Ogawa, Takuya Yashiro and Chiharu Nishiyama
BBRC, Volume 530, Issue 1, 10 September 2020, Pages 342-347 -
Methods for Automated Single Cell Isolation and Sub‐Cloning of Human Pluripotent Stem Cells
Valeria Fernandez Vallone Narasimha Swamy Telugu Iris Fischer Duncan Miller Sandra Schommer Sebastian Diecke Harald Stachelscheid
Current Protocols in Stem Cell Biology,Volume55, Issue1,December 2020,e123 First published: 21 September 2020 -
Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and animal origin-free media
Keisuke Sekine, Shimpei Ogawa, Syusaku Tsuzuki, Tatsuya Kobayashi, Kazuki Ikeda, Noriko Nakanishi, Kenta Takeuchi, Eriko Kanai, Yugo Otake, Satoshi Okamoto, Tsuyoshi Kobayashi, Takanori Takebe & Hideki Taniguchi
Scientific Reports volume 10, Article number: 17937 (2020) -
Functional analysis of isoflavones using patient-derived human colonic organoids
MaoTsuchiya, GoIto,MinamiHama, SayakaNagata, AmiKawamoto, KoheiSuzuki, HiromichiShimizu, ShoAnzai, JunichiTakahashi, ReikoKuno, SayakaTakeoka, YuiHiraguri, HadyYukiSugihara, TomohiroMizutani, ShiroYui, ShigeruOshima, KiichiroTsuchiya, MamoruWatanabe, RyuichiOkamoto
Biochemical and Biophysical Research Communications, Volume 542, 26 February 2021, Pages 40-47
Cell3iMager neo
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Phenotypic Drug Discovery in 3D, Testing Drug Efficacy by Rapid Size ProfilingOver Time with Tumor MicrotissuesRandy Strube, Ph.D., Andreia F.Fernandes, Markus Furter, Jens M. Kelm,Ph.D., and David A. Fluri, Ph.D.
Genetic Engineering & Biotechnology News, (2014), Vol. 34, No. 16. -
Human Dynactin-Associated Protein Transforms NIH3T3 Cells to Generate Highly Vascularized Tumors with Weak Cell-Cell InteractionJTatsuki Kunoh, Weixiang Wang, Hiroaki Kobayashi, Daisuke Matsuzaki, Yuki Togo, Masahiro Tokuyama, Miho Hosoi, Koichi Koseki, Shu-ichi Wada, Nobuo Nagai, Toshinobu Nakamura, Shintaro Nomura, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami.
PLOS ONE, (2015), August 18. -
Three-Dimensional Spheroid Cell Culture Model for Target Identification Utilizing High-Throughput RNAi ScreensLaKesla R. Iles, Geoffrey A. Bartholomeusz.
High-Throughput RNAi Screening (2016), 21-135. -
PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells
Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Tatsuro Murano, Go Ito, Hiromichi Shimizu, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Akihiro Araki, Kazuo Ohtsuka, Ryuichi Okamoto, Mamoru Watanabe.
Scientific Reports, (2016), 36795. -
PAF promotes stemness and radioresistance of glioma stem cells
Derrick Sek Tong Ong, Baoli Hu, Yan Wing Ho, Charles-Etienne Gabriel Sauvé, Christopher A. Bristow, Qianghu Wang, Asha S. Multani, Peiwen Chen, Luigi Nezi, Shan Jiang, Claire Elizabeth Gorman, Marta Moreno Monasterio, Dimpy Koul, Matteo Marchesini, Simona Colla, Eun-Jung Jin, Erik P. Sulman, Denise J. Spring, Wai-Kwan Alfred Yung, Roel G. W. Verhaak, Lynda Chin, Y. Alan Wang, and Ronald A. DePinho
PNAS October 24, 2017 114 (43) -
Single cell analysis of Crohn’s disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties
Kohei Suzuki, Tatsuro Murano, Hiromichi Shimizu, Go Ito, Toru Nakata, Satoru Fujii, Fumiaki Ishibashi, Ami Kawamoto, Sho Anzai, Reiko Kuno, Konomi Kuwabara, Junichi Takahashi, Minami Hama, Sayaka Nagata, Yui Hiraguri, Kento Takenaka, Shiro Yui, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto.
Journal of Gastroenterology, (2018), 1–13. -
Sertraline, chlorprothixene, and chlorpromazine characteristically interact with the REST-binding site of the corepressor mSin3, showing medulloblastoma cell growth inhibitory activities
Jun-ichi Kurita, Yuuka Hirao, Hirofumi Nakano, Yoshifumi Fukunishi & Yoshifumi Nishimura.
Scientific Reports 8, Article number: 13763 (2018). -
Up-regulation of Bone Morphogenetic Protein 7 by 2-Hydroxycinnamaldehyde Attenuates HNSCC Cell Invasion
SUNG-MIN KANG1, JINKYUNG KIM1, SOO HYUN KANG1, SU YOUNG OH1, HEON-JIN LEE1, BYOUNG-MOG KWON2 and SU-HYUNG HONG1
Anticancer Research October 2018 vol. 38 no. 10 5747-5757 -
Acquired JHDM1D–BRAF Fusion Confers Resistance to FGFR Inhibition in FGFR2-Amplified Gastric Cancer
Hitoshi Sase, Yoshito Nakanishi, Satoshi Aida, Kana Horiguchi-Takei, Nukinori Akiyama, Toshihiko Fujii, Kiyoaki Sakata, Toshiyuki Mio, Masahiro Aoki and Nobuya Ishii
Molecular cancer theraputics-17-1022 Published October 2018 -
Automated, high-throughput measurement of size and growth curves of small organisms in well plates
James Duckworth, Tjalling Jager & Roman Ashauer
Scientific Reportsvolume 9, Article number: 10 (2019) -
A novel electron emission-based cell culture device promotes cell proliferation and differentiation of pre-osteoblastic MC3T3-E1 cells
Fumiaki Sugimori, Hiroyuki Hirakawa, Ai Tsutsui, Hiroyuki Yamaji, Shohei Komaru, Mai Takasaki, Tadashi Iwamatsu, Toshimasa Uemura, Yo Uemura, Kenichi Morita, Takashi Tsumura
PLOS, March 28, 2019 -
Monospecific antibody targeting of CDH11 inhibits epithelial-to-mesenchymal transition and represses cancer stem cell-like phenotype by up-regulating miR-335 in metastatic breast cancer, in vitro and in vivo
Jia-Hong Chen, Wen-Chien Huang, Oluwaseun Adebayo Bamodu, Peter Mu-Hsin Chang, Tsu-Yi Chao & Tse-Hung Huang
BMC Cancer volume 19, Article number: 634 (2019 -
Wild-type TP53 defined gamma-secretase inhibitor sensitivity and synergistic activity with doxorubicin in GSCs
Chen Zhang, Emmanuel Martinez-Ledesma, Feng Gao, Wei Zhang, Jie Ding, Shaofang Wu, Xiaolong Li, Jimin Wu, Ying Yuan, Dimpy Koul, and WK Alfred Yung
Am J Cancer Res. 2019; 9(8): 1734–1745. 2019 Aug 1. -
A 3D Heterotypic Multicellular Tumor Spheroid Assay Platform to Discriminate Drug Effects on Stroma versus Cancer Cells
Zoe Weydert, Madhu Lal-Nag, Lesley Mathews-Greiner, Christoph Thiel, Henrik Cordes, Lars Küpfer, Patrick Guye, Jens M. Kelm, Marc Ferrer
SLAS Volume: 25 issue: 3, page(s): 265-276 October 29, 2019 -
Promoter-Level Transcriptome Identifies Stemness Associated With Relatively High Proliferation in Pancreatic Cancer Cells
Ru Chen, Aiko Sugiyama, Naoyuki Kataoka, Masahiro Sugimoto, Shoko Yokoyama, Akihisa Fukuda, Shigeo Takaishi and Hiroshi Seno
Frontiers in Oncology Gastrointensitial Cancers, 20 March 2020 -
Parallelized Wireless Sensing System for Continuous Monitoring of Microtissue Spheroids
Lei Dong, Paolo S. Ravaynia, Qing-An Huang, Andreas Hierlemann, and Mario M. Modena
ACS Sens. 2020, 5, 7, 2036–2043, Publication Date:June 10, 2020 -
Preclinical Evaluation of the Novel Small-Molecule MSI-N1014 for Treating Drug-Resistant Colon Cancer via the LGR5/β-catenin/miR-142-3p Network and Reducing Cancer-Associated Fibroblast Transformation
Vijesh Kumar Yadav, Yan-Jiun Huang, Thomashire Anita Georg, Po-Li Wei, Maryam rachmawati Sumitra, Ching-Liang Ho, Tzu-Hao Chang, Alexander T. H. Wu and Hsu-Shan Huang
Cancers 2020, 12(6), 1590; Published: 16 June 2020 -
Co-Microencapsulation of Islets and MSC CellSaics, Mosaic-Like Aggregates of MSCs and Recombinant Peptide Pieces, and Therapeutic Effects of Their Subcutaneous Transplantation on Diabetes
Yusuke Mochizuki, Ryo Kogawa, Ryuta Takegami, Kentaro Nakamura, Akira Wakabayashi, Tadashi Ito and Yasuhiro Yoshioka
Biomedicines 2020, 8(9), 318; Published: 31 August 2020 -
PREDICTING METABOLISM-RELATED DRUG-DRUG INTERACTIONS USING A MULTI-TISSUE MICROPHYSIOLOGICAL SYSTEM
Christian Lohasz, Flavio Bonanini, Kasper Renggli, Olivier Frey, and Andreas Hierlemann.
ETH Zurich NO. 26595, 2020